Gobbi A, Albanese D, Iorio F, Jurman G and . JS (2015). BiRewire: High-performing routines for the randomization of a bipartite graph (or a binary event matrix) and directed signed graph preserving degree distribution (or marginal totals).. R package version 2.2.3, http://www.ebi.ac.uk/~iorio/BiRewire.